Cerebral metabolic studies in vivo by combined1H/31P and1H/13C NMR spectroscopic methods
نویسندگان
چکیده
منابع مشابه
NMR studies of compartmentalized cerebral carbohydrate metabolism
Localized 13C nuclear magnetic resonance (NMR) spectroscopy provides a unique window for studying cerebral carbohydrate metabolism through, e.g. the completely non-invasive measurement of cerebral glucose and glycogen metabolism. In addition, label incorporation into amino acid neurotransmitters such as glutamate (Glu), GABA and aspartate can be measured providing information on Krebs cycle flu...
متن کاملCombined 1H and 31P NMR studies of cerebral metabolism in vivo.
NMR spectroscopic methods have recently been developed for measurement of several concentrated cerebral metabolites in vivo. At present, 31P spectra from the brain permit detection of ATP, PCr, Pi, and certain sugar and lipid phosphates. The resonant frequency of Pi also provides a measure of cerebral pHi, and under some conditions ADP concentration can be calculated from information available ...
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Statistical methods for helping characterise and make sense of spectroscopic data are of growing importance in biological research. The quantity of data describing biological objects and systems produced on a daily basis continues to increase, going hand-in-hand with developments in high-throughput techniques, assay multiplexing, minaturisation using nanofluidic devices, and, more commonly, wit...
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Objective(s): Unstable angina (UA) is a form of the acute coronary syndrome (ACS) that affects more than a third of the population before age 70. Due to the limitations of diagnostic tests, appropriate identification of UA is difficult. In this study, we proceeded to investigate metabolite profiling in UA patients compared with controls to determine potential candidate...
متن کاملIn Vivo Assessment of Neuronal Metabolic Fluxes in Mouse Brain by H-[C] NMR Spectroscopy
Introduction In vivo C NMR spectroscopy in conjunction with the administration of C labeled substrates has been intensively used to assess cerebral metabolism in human and rat. C MRS studies of transgenic mouse models will provide insights into the metabolism in brain pathologies. However, the intrinsically low sensitivity of C MRS and the small size of the mouse brain remain limiting factors f...
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ژورنال
عنوان ژورنال: Acta Neurochirurgica
سال: 1993
ISSN: 0001-6268,0942-0940
DOI: 10.1007/bf01809281